• News
  • Medical

With strict regulation, gene editing is our future

With strict regulation, gene editing is our future

Mitalipov's work, by contrast, involved human embryos that he and his team created with sperm donated by men who had the genetic mutation leading to the heart disease they were trying to edit out of the embryos.

Scientists for the first time have successfully edited genes in human embryos to fix a common and serious disease-causing mutation, producing apparently healthy embryos, according to a study published on Wednesday.

Scientists at Oregon Health and Science University (OHSU), with colleagues in California, China and South Korea, reported that they repaired dozens of embryos, fixing a mutation that causes a common heart condition that can lead to sudden death later in life. There are two major scenarios in which editing the DNA of an embryo might be considered ethical: One in which both parents carry a gene for a genetic disorder recessively, and one in which one parent carries a dominant gene for a disease, like hypertrophic cardiomyopathy or Huntington's disease. But they also acknowledged that they will continue to move forward with the science, with the ultimate goal of being able to "correct" disease-causing genes in embryos that will develop into babies. But although the NIH won't back CRISPR research for embryo editing, that doesn't mean such research is prohibited in the U.S. Private organizations and donors fund researchers.

This study was a pre-clinical test created to examine the technique's safety and effectiveness, and while further optimization is needed before clinical trials can be considered, the results are promising.

The team used CRISPR to target the abnormal genes as the cells in the embryo divided, and changed them out for a properly functioning type of gene.

The scientists said that CRISPR-Cas9, combined with in vitro fertilization, could be helpful for many other genetic diseases once more clinical studies are carried out.

United States carriers offer Motorola's Z2 Force Edition smartphone
We should also note, the Moto Z2 Force is the first handset include a new Moto Key - which is a security and password manager. Moto announced the phone at a NY press event, and confirmed that it will be coming to the United Kingdom in due course.

The researchers found that 72.4 percent of the embryos, not 50 percent as would have been expected, were free of the errant gene. The research team cleverly side-stepped mosaicism by using CRISPR at the same time as fertilising the egg, before its cells had begun dividing. Natural DNA-repair mechanisms in the cell follow up by filling in the missing pieces. In this particular experiment, the researchers used CRISPR-Cas9 on 58 embryos containing the mutation. In addition, there are thousands of genetic diseases wherein the same procedure could be applied. The Salk scientists contributed by developing the gene editing strategy, initially testing it in stem cells derived from the patient's skin cells.

Currently, the most reliable way of screening for such inherited defects is by using IVF, screening the resulting embryos for the mutation and transferring only those without the mutation for pregnancy.

"The ethical considerations of moving this technology to clinical trials are complex and deserve significant public engagement before we can answer the broader question of whether it's in humanity's interest to alter human genes for future generations", said Daniel Dorsa, PhD, SVP of research at OHSU.

And Congress has banned the US Food and Drug Administration (FDA) from even considering the possibility of human clinical trials involving embryos with edited inherited genes. In the new study, researchers discarded the embryos a few days after fertilisation. Think of it as a biological cut-and-paste program.

Earlier this year, an ethics report from the prestigious National Academy of Sciences opened the door to lab research to figure out how to make such changes - but said if germline editing ever is allowed, it should be reserved for serious diseases with no good alternatives and performed under rigorous oversight.

Meanwhile, critics worry about attempts at "designer babies" instead of just preventing disease.

Leave Your Comment

Leave Your Comment


Latest News

  • For Trump, the honeymoon with Putin may be finally over

    For Trump, the honeymoon with Putin may be finally over

    President Donald Trump plans to sign a bill into law that would tighten sanctions against Iran, Russia and North Korea . If he opts for a veto, the bill can become law anyway if two-thirds of both the House and Senate vote for an override.
    Trump Tweets Major White House Shake-up

    Trump Tweets Major White House Shake-up

    During much of the phone call he focused on his conviction that Mr Priebus had "c***-blocked" and orchestrated leaks against him. Now, we know that Sean Spicer , the former - or outgoing, rather - press secretary, also had some issues with Scaramucci.
    Adam Peaty defends 50m breaststroke title

    Adam Peaty defends 50m breaststroke title

    Staffordshire swimmer Adam Peaty has won another gold medal at the Swimming World Championships in Budapest . He can keep that up for 50m, but not for a 100m - that's why he went to 25.95 seconds.
  • Teen jumps from plane onto SFO tarmac

    Teen jumps from plane onto SFO tarmac

    SFO spokesperson Doug Yakel confirmed that no runways were affected and there was no operational impact from the incident . An airport construction crew working nearby confronted the boy and held him until police arrived and arrested him.
    State Journal editorial: Trump targets loyal troops with tweets

    State Journal editorial: Trump targets loyal troops with tweets

    As if he doesn't have enough controversy to contend with, President Donald Trump created yet another distraction last week. ABC2 spoke with a highly decorated member of the military , who now feels like she's in limbo.
    OPEC & non-OPEC producers agree to curb oil output

    OPEC & non-OPEC producers agree to curb oil output

    The Russian minister also said that the countries managed to reduce the surplus of commodity stocks of oil and oil products. Opec states Libya and Nigeria were exempted from the limits to help their oil industries recover from years of unrest.
  • Iran Says US Navy Vessel Fired Warning Shots

    Iran Says US Navy Vessel Fired Warning Shots

    According to information, a military helicopter flied from Nimitz-class aircraft carrier and came close to Iran's rocket boat. McConnaughey called the move "safe and professional". "A strong answer will be given to the action by the U.S. ", he said.
    Russian lawyer who met Donald Trump's son worked for intelligence agency

    Russian lawyer who met Donald Trump's son worked for intelligence agency

    The 2016 meeting happened after the president's eldest son was offered potentially damaging information about Hillary Clinton . Veselnitskaya "without a doubt" acted on behalf of the Russian government to create "chaos" in the American political system.
    US Navy Ship Fires Warning Shots Near Iranian Vessel In Persian Gulf

    US Navy Ship Fires Warning Shots Near Iranian Vessel In Persian Gulf

    The U.S. official said it was "out of the norm" for an Iranian military ship to "come in that close at that rate of speed". He said the Iranian ship backed away after the warning shots were fired.
  • Microsoft Paint Saved by Outpouring Love from Fans

    Microsoft Paint Saved by Outpouring Love from Fans

    Microsoft said in a blog post it saw an "incredible outpouring of support and nostalgia around MS Paint " on Monday. The listed programs were disclosed as parts of the Windows 10 Fall Creators Update , which spin out in the autumn.
    Sony sees recovery with a almost  quadrupling of profit

    Sony sees recovery with a almost quadrupling of profit

    The recovery of the image sensor business from last year's natural disaster saw the operation make a profit of $500 million. Sales also experienced a 17% increase on a constant currency basis over last year's ¥141.9 billion ($1.29 billion).
    Charlie Gard's Parents Drop Request to Let Him Die at Home

    Charlie Gard's Parents Drop Request to Let Him Die at Home

    The parents' lawyer conceded that the home option was not possible, but asked for more time to try to find an alternative. Both his parents and doctors have agreed that he should move to a hospice, Mr Justice Francis heard.
  • Trump told Fox News to run Seth Rich conspiracy story, lawsuit alleges

    Trump told Fox News to run Seth Rich conspiracy story, lawsuit alleges

    Wheeler's suit may indeed be a moneymaking scheme, as Butowsky now claims as he denies it all. Wheeler has been contributing to Fox News for more than a decade, even through this weekend.

    Starbucks to shutter all Teavana stores as sales disappoint

    On Thursday, Starbucks said it shell out $1.3 billion to buy out its joint venture partners in its East China business. Starbucks says it will close all of its 300+ Teavana stores over the coming year.
    World oil prices exceed $51

    World oil prices exceed $51

    WTI oil prices are forecast at $48.95 per barrel in 2017 and $49.58 per barrel in 2018, according to the EIA. Gasoline stocks fell by one million barrels, compared with analyst expectations for a 614,000-barrel drop.
  • Ray Lewis urges Kaepernick to keep activism private

    Ray Lewis urges Kaepernick to keep activism private

    Kaepernick would have likely been a replacement for backup quarterback Ryan Mallett , who has had some difficulties at practice. Meanwhile, over the weekend, Bisciotti said that he had been asked by a fan about Kaepernick hurting the organization's brand .
    Moscow cuts United States  diplomatic staff in response to sanctions

    Moscow cuts United States diplomatic staff in response to sanctions

    Congress gave bilateral approval to a new slate of sanctions on Russian Federation over its interference in the 2016 election. The Russian Foreign Ministry warned it would respond in kind if Washington made a decision to expel any Russian diplomats.
    Chargers acquire quarterback Cardale Jones from Bills for conditional draft pick

    Chargers acquire quarterback Cardale Jones from Bills for conditional draft pick

    The 6-foot-5, 250-pound quarterback led Ohio State to a National Championship in 2014, but lost the Buckeyes starting role to J.T. Jones saw his only regular season action in that controversial week 17 game against the Jets where Tyrod Taylor was benched.

Breaking News



Recommended

Samsung Launches Flip Phone SM-G9298 With Dual Displays

There are two 4.2-inch Super AMOLED full HD displays on hand here, with one placed on the outside and the other on the inside. Similar to the Samsung Galaxy S8 and Galaxy S8+, the flip phone does not come with a dedicated button for Samsung's Bixby.

HSBC to Buy Back Up to $2 Billion in Shares

HSBC has reported a rise in half-year profit and announced a two billion United States dollar (£1.5 billion) share buy-back. The bank reported a profit of $3.9 billion in the second quarter, compared with $2.5 billion in the second quarter of 2016.

CORPORATE REPORT: Charter, Sprint and HSBC

Claure said that "we think in the near future, we should be able to strike a deal with one of the different players". Earnings per share came to 5 cents, trouncing analysts' forecast of a roughly 1-cent loss.

RS polls: Amit Shah, Smriti Irani and Rajput file nominations

BJP national president Amit Shah filed the nomination papers for the Rajya Sabha elections from Gujarat on Friday morning. Rajput, along with two other leaders, joined BJP after quitting Congress on Thursday.

Trump replaces chief of staff Priebus with general Kelly

As Secretary of Homeland Security, Kelly has played a key role in the border security of the Trump Administration. As for Kelly, until now, he was US Secretary of Homeland Security, nominated by Trump on December 2, 2016.

Putin says Russian Federation fed up with U.S. insolence

When House leadership took up the bill , they added additional sanctions on Iran and North Korea. It also proposes sanctions on North Korea and Iran for their ballistic missile programmes.

German Auto-Majors May Have Colluded In Biggest Cartel Scandal In History

Owned by the Volkswagen Group, Audi, the luxury auto brand announced the voluntary upgrade of the diesel vehicles this Friday. Now, BMW has become the first manufacturer to officially react to those allegations, issuing an official statement.

18-Year-Old Girl Livestreams Car Crash That Killed Her Sister

Jacqueline was about to celebrate her quincenera - the Hispanic tradition of honoring someone's coming of age at 15-years-old. Meanwhile, the family of her sister have set up a GoFundMe page to pay for her funeral expenses.

SDCC 2017: Captain Marvel Will Be Set In The 1990's

In the regular Marvel Comics continuity, Carol Danvers made her first appearance in 1968's Marvel Super-Heroes #13. We still haven't seen much of Captain Marvel , but today Marvel gave us a few more details about the movie.

Jose Mourinho Rules Out Manchester United Move For Gareth Bale

Woodward and analysing from a distance, it is very hard . So I am happy and 100% he stays with us". He is a very honest, straight boy.